The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Biomarkers, 2007Prospective Validation of Risk Markers for the Development of Parkinson’s Disease
Objective/Rationale:
The development of disease-course modifying or neuroprotective treatments is still an unmet therapeutical need in Parkinson’s disease. Treatment will likely work best if initiated... -
Therapeutics Development Initiative, 2006Preclinical Evaluation of a 5-HT2A Antagonist for Treatment of L-DOPA-Induced Dyskinesias in Parkinson's Disease
The primary motor deficits of Parkinson's disease are effectively improved by administration of the dopamine precursor L-dihydroxyphenylalanine, or levodopa. For unknown reasons, levodopa loses...
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Therapeutics Development Initiative, 2006Treatment of Parkinson’s Disease with AT2101, a compound that increases the activity of endogenous Glucocerebrosidase
Genetic association studies have suggested a link between Parkinson's and Gaucher disease. Gaucher disease is a lysosomal storage disorder caused by mutations in the gene GBA, which results in a loss...
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Therapeutics Development Initiative, 2006PN277: A NEURO- RESTORATIVE, PROTECTIVE PRODUCT FOR PARKINSON’S DISEASE
Acute and chronic neurodegenerative disorders such as Parkinson's disease, stroke, head trauma, spinal cord injury, Huntington's, Alzheimer's and ALS affect millions of people worldwide. Currently...
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Therapeutics Development Initiative, 2006Develop Engineered Zinc Finger Protein Transcriptional Activators of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene as a Potential Therapy for Parkinson's Disease
Engineered zinc finger protein transcription factors (ZFP TFs) are an emerging class of molecules with the potential for broad therapeutic impact in the treatment of human disease. ZFP TFs function by...
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Community Fast Track, 2006Investigating Defects in Mitochondrial Functions, Transport, Fusion/Fission in LRRK2 Pre-clinical ModelsThe study of genetic forms of Parkinson’s disease is important for revealing the mechanisms of pathogenesis, and for future therapeutic developments. LRRK2 is the recently identified gene for Park8...
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Our funding programs support basic, translational and clinical research from academia and industry.