The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024Investigating the Effects of Pesticide Exposure on Immune System Function in Parkinson’s Disease
Study Rationale: Although it is well known that exposure to environmental substances, including pesticides, contributes considerably to Parkinson’s disease (PD), the mechanisms are largely unexplored...
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ASAP CRN Competitive Renewal Opportunity, 2024Studying the Pathogenesis of Parkinson’s Disease Via Single-cell Analysis of Human Brain and Gut Cells: A Basis for Clinical Translation
Study Rationale: More than 100 regions of the chromosomes that we inherit from our parents show differences in DNA sequence between people with and without Parkinson’s disease (PD). Furthermore, as we...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Phase 2a Clinical Study of HBI-002 in Parkinson’s Disease
Study Rationale: A growing body of research suggests that low doses of carbon monoxide (CO) protect against neuronal cell loss in Parkinson’s disease (PD). Preclinical efficacy data in two rodent...
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ASAP CRN Competitive Renewal Opportunity, 2024Identifying Mechanisms that Overwhelm Protein and Organelle Quality Control in Parkinson’s Disease
Study Rationale: Abnormal protein aggregation and prion-like aggregate spreading are hallmarks of the degenerative cascades of sporadic and familial Parkinson’s disease (PD). These toxic aggregates...
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ASAP CRN Competitive Renewal Opportunity, 2024IMPACT-PD: Implications of Polyamine and Glucosylceramide Transport in Parkinson’s Disease
Study Rationale: Mutations in the genes ATP13A2, GBA1 and ATP10B trigger Parkinson’s disease (PD) and cause dysfunction of lysosomes, the recycling compartments of the cell. These genes regulate the...
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Measuring Alpha-Synuclein in Extracellular Vesicles, 2024Measuring Alpha-synuclein in Extracellular Vesicles: A Biomarker for the Diagnosis and Staging of Neuronal α-Synuclein Diseases
Study Rationale: Parkinson's disease (PD) and dementia with Lewy bodies involve accumulation of alpha-synuclein in neurons. A recently developed test for alpha-synuclein aggregates in cerebrospinal...
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Our funding programs support basic, translational and clinical research from academia and industry.