The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2020Parkinson’s Disease with Mild Cognitive Impairment Treated with a Nicotinic Agonist Drug
Study Rationale:
Parkinson’s disease with mild cognitive impairment (PD-MCI) is common, has important clinical consequences, and there is currently no treatment available. The underlying pathology of... -
Therapeutic Pipeline Program, 2020Identification and Characterization of Small Molecule Activators of ATP13A2 for Parkinson’s Disease Therapy
Study Rationale:
In Parkinson’s disease, neurons degenerate because of a disturbed function of the lysosomes and mitochondria. The lysosomal transporter ATP13A2 (PARK9) is genetically implicated in... -
Target Advancement Program, 2020Identification of ASC as a Disease-modifying Therapeutic Target in Parkinson’s Disease
Study Rationale:
Inflammasomes are large multiprotein complexes that play a central role in the innate immune system, the body’s first line of defense against microbes. Inflammasomes are key drivers... -
Research Grant, 2020Targeting of the Raphe-Cortical Pathway to Reduce Levodopa-Induced Psychosis
Study Rationale:
Parkinson’s disease is best known as a movement disorder, yet non-motor symptoms such as anxiety, depression and psychosis afflict over 50 percent of patients and severely impact... -
Biosample Use Program, 2020CSF RT-QuIC Alpha-Synuclein Amplification in LRRK2-Parkinson’s Disease
Study Rationale:
Parkinson’s disease caused by genetic mutations in the gene called leucine rich repeat kinase 2 (LRRK2) is clinically indistinguishable from idiopathic Parkinson’s disease, in which... -
Aligning Science Across Parkinson's, 2020Impaired Integration of Organelle Function in Parkinson’s Disease
Study Rationale:
Geneticists have made great progress in identifying gene mutations that either cause Parkinson’s or increase disease risk. The critical next step is to determine how some of these...
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Our funding programs support basic, translational and clinical research from academia and industry.