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PROGENI Family Study
… We have previously recruited over 800 families having multiple members diagnosed with PD. About 5% of these … In addition, we will also recruit control families having multiple members with PD, but who do not have a LRRK2 …
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Development of a Sensitive Assay to Correlate LRRK2 Kinase Activity and Conformational State
… is present alone (as a monomer) or in a large complex with multiple LRRK2 molecules, and then directly measure its … known as size-exclusion chromatography. We will then assess multiple aspects of LRRK2 kinase activity simultaneously; …
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MJFF Scientist Among Featured Speakers at Neurodegenerative Drug Development Summit
February 5, 2020
… disorders—which include Parkinson’s, Alzheimer’s, ALS, and multiple sclerosis, and others—have many features and … the three-day Neurodegenerative Drug Development Summit. Multiple companies that have received support from MJFF are …
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Toshiya Nishi, DVM
… During his career as a pharmacologist, Dr. Nishi has led multiple drug discovery programs in diverse therapeutic …
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MJFF Alpha-Synuclein Mouse Comparison Study
August 30, 2023
… Download PDF MJFF funded a study to compare multiple common alpha-synuclein mouse models to understand …
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Development of Novel Brain-penetrant Inflammasome Inhibitors as Potential Therapeutics for Parkinson’s Disease
… Study Rationale: The immune system displays an aberrant pattern of activity in the central nervous system of people with Parkinson’s disease (PD); this pattern …