The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
The Role of Protein Degradation in Parkinson's Disease, 2002Role of Autophagic-Lysosomal Pathway in the Degradation of Alpha-Synuclein Aggregates
Many human neurological diseases, including Parkinson's disease, Alzheimer's disease, and Huntington's disease, are associated with abnormal levels of protein buildup inside brain cells (neurons). A...
-
The Role of Protein Degradation in Parkinson's Disease, 2002Proteomic analysis of accumulated proteins in dopaminergic neurons using a pre-clinical model ofubiquitin-proteasome system dysfunction
Damaged or unnecessary proteins are normally removed from a cell after they are tagged by attachment of a small protein called ubiquitin. These ubiquitin-tagged proteins are then recognized by a large...
-
The Role of Protein Degradation in Parkinson's Disease, 2002PARKIN SUBSTRATES, SYUNCLEIN AND TAU AND THEIR ROLE IN PROTEASOME
Degenerative disease of the central nervous system, such as Alzheimer's and Parkinson's disease, are characterized by the accumulation of abnormal protein deposits. Recent studies of patients...
-
The Role of Protein Degradation in Parkinson's Disease, 2002Elucidation of the Role of Parkin in the Ubiquitin-Proteasome Degradation Pathway in Parkinson's Disease
Parkinson's disease is one of the most common movement disorders, severely affecting people by causing intense shaking and sometimes complete freezing of movement. This disease is caused by the death...
-
The Role of Protein Degradation in Parkinson's Disease, 2002Characterization of Dopaminergic Neurons in a Proteasome-transgenic Pre-Clinical Model
Almost all cells in the human body are constantly degrading old, often damaged proteins, a process that prevents the formation of protein aggregates and is vital to keep the cell alive and functioning...
-
The Role of Protein Degradation in Parkinson's Disease, 2002In vivo functional and molecular studies in a new model of Parkinson's disease generated usingviral vectors to deliver human alpha-synuclein
Parkinson's disease (PD) is a progressive neurological disorder characterized by degeneration of the dopaminergic neurons of the substantia nigra. Although the majority of the cases appear...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.