The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Resource: Utilizing DATATOP Biospecimens, 2011Identification and Validation of Blood-borne Autoantibody Biomarkers for Parkinson's Disease
Objective/Rationale:
We recently discovered that self-reactive antibodies (autoantibodies) are abundant in blood and that detection of certain types of autoantibodies reveals the presence of disease... -
LRRK2, 2011Impact of LRRK2 Kinase Activity on Synaptic Vesicle Trafficking
Objective/Rationale:
The presynaptic alteration seen in several LRRK2 disease model suggest that LRRK2 might influence synaptic function through effects on presynaptic proteins. The common G2019S... -
Biomarkers, 2011GSTpi as a Blood Based Biomarker for Parkinson's Disease
Objective/Rationale:
The goal of this research project is to develop and validate a blood test that would identify individuals at risk for developing Parkinson’s disease and at a point in time prior... -
MJFF Research Grant, 2011Multi-tracer positron emission tomography (PET) functional imaging as a tool to assess the relevance of rodent LRRK2 models to the human neurochemical phenotype associated with LRRK2 mutations related Parkinsonism
Promising Outcomes of Original Grant:
The goals of the original grant were to develop PET (a non invasive imaging technique used in the study of human Parkinson’s disease ) –derived measures of... -
LRRK2, 2011LRRK2 Role on Auto-Antibody Production by Human B Cells
Objective/Rationale:
LRRK2 expression has been demonstrated in the brain and several organs, including the thymus and spleen, which are major immune system organs for B and T lymphocyte maturation... -
Rapid Response Innovation Awards, 2011Functional Characterization of ATP13A2, a P-type Transport ATPase Involved in Neurodegeneration
Objective/Rationale:
Mutations in the ATP13A2 gene lead to the Kufor-Rakeb syndrome, a severe early-onset form of Parkinson’s disease (PD) with dementia. The ATP13A2 protein is targeted to cellular...
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Our funding programs support basic, translational and clinical research from academia and industry.