To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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ROSA SNCA Knockout Mouse*
Mice carrying SNCA knockout allele and Gt(ROSA)26Sor Cre reporter allele. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028560
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Alpha-Synuclein Knockout Mouse*
SCNA knockout mice carrying a 1164 bp fragment deletion in exon 2. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028559
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Human Parkin Mouse*
Transgenic mice expressing wild type human Parkin under the direction of the mouse prion protein promoter. Model was generated and deposited by Konstanze Winklhofer at Ruhr University Bochum through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:027630
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Mfn2 LoxP Floxed Mouse*
Mice with LoxP sites flanking Mfn2 exon 6. Model was generated and deposited by David Chan at California Institute of Technology through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:026525
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SNCA Floxed Mouse*
Mice with loxP sites flanking SNCA exon 2. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:025636
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LRRK2 Wild Type Overexpression Mouse*
Hemizygous BAC LRRK2 mice that overexpress wild type human LRRK2 directed by the human LRRK2 promoter/enhancer regions on the BAC transgene. Model was generated and deposited by Chenjian Li at Mount Sinai School of Medicine through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:009610
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LRRK2 G2019S Mouse*
Transgenic mice expressing human LRRK2 G2019S mutation directed by the human LRRK2 promoter/enhancer regions on the BAC transgene. Model was generated and deposited by Chenjian Li at Mount Sinai School of Medicine through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:009609
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Parkin Q311X Mouse*
Transgenic mice carrying a FLAG-tagged C-terminal truncated human Parkin Q311X mutation. Model was generated and deposited by X. William Yang at University of California Los Angeles through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:009090
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic