To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Human Alpha-Synuclein Mouse*
Homozygous knockout of endogenous wild type mouse alpha-synuclein and replaced with the full human alpha synuclein gene and 34kb of its upstream region. Model was generated and deposited by Robert Nussbaum at University of California San Francisco through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:010710
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Human Alpha-Synuclein A53T Mouse*
Transgenic mice expressing the A53T missense mutant form of human alpha-synuclein under the control of the murine prion promoter. Model was generated and deposited by Michael Lee at University of Minnesota through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:006823
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Parkin Knockout Mouse*
Homozygous knockout mice with exon 3 mutation resulting in a frame shift and a premature stop codon in exon 5. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:006582
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Alpha-Synuclein A53T Knockin Mouse*
Double transgenic homozygous mice with abolished endogenous mouse alpha synuclein expression replaced with the human A53T alpha synuclein mutant form. Model was generated and deposited by Robert Nussbaum at University of California San Francisco through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:010799
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GBA E326K Knockin Mouse*
Mouse expressing GBA E326K mutation and 3 silent mutations in exon 8 of the mouse Gba gene. Model was generated and deposited by Mark Cookson at NIH through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:036159
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MCI-PARK Mouse*
Homozygous knockout mice targeting Ndufs1 (NADH:ubquinone oxidoreductase core subunit S2) specifically in dopaminergic neurons. Mice with floxed Ndufs2 allele were crossed with mice expressing Cre recombinase under the control of Slc6ac (dopamine transporter; DAT) promoter. Model was generated and deposited by D. James Surmeier at Northwestern University through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:036313
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SNCA-GFP Knockin Mouse*
Mouse expressing SNCA with GFP fused to the C-terminus resulting in expression of GFP-tagged alpha-synuclein under the control of endogenous regulatory elements. Model was generated and deposited by Kelvin Luk at University of Pennsylvania through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:035412
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LRRK2 pT1410 Phosphospecific Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine1410 of LRRK2. Antibody is suitable for immunoblotting applications.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic