To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Alpha-Synuclein A30P/A53T Mouse*
Transgenic mice expressing double mutant form of human alpha synuclein containing A30P and A53T under the control of the rat tyrosine hydroxylase promoter. Model was generated and deposited by Eric Richfield at Rutger’s University through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:008239
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ROSA26 LRRK2 R1441C Mouse*
Mice carrying human LRRK2 R144C mutation inserted into the endogenous Gt(ROSA)26Sor locus. Model was generated and deposited by Darren Moore at Van Andel Research Institute through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:026293
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LRRK2 Y1699C Mouse*
Transgenic mice expressing LRRK2 Y1699C mutation. Model was generated and deposited by Heather Melrose at Mayo Clinic College of Medicine and Matthew Farrer at University of British Columbia through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:021913
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LRRK2 Knockout Mouse*
LRRK2 knockout with the LRRK2 exon 41 deleted. Model was generated and deposited by Matthew Farrer at University of British Columbia through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:012444
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LRRK2 Knockout Mouse*
LRRK2 knockout mice with the LRRK2 exons 29-30 deleted. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016210
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LRRK2 Knockout Mouse*
LRRK2 knockout mice with the LRRK2 promoter and exon 1 deleted. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016209
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LRRK2 R1441C Mouse*
Transgenic mice expressing full length LRRK2 with R1441C mutation driven by CMV enhancer and PDGFB promoter/enhancer elements. Model was generated and deposited by Darren Moore at Van Andel Research Institute and Valina Dawson at Johns Hopkins University through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016576
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LRRK2 G2019S Mouse*
Transgenic mice expressing full length LRRK2 with G2019S mutation driven by CMV enhancer and PDGFB promoter/enhancer elements. Model was generated and deposited by Darren Moore at Van Andel Research Institute and Valina Dawson at Johns Hopkins University through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016575
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic