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![Illustrated close up of DNA.](/sites/default/files/styles/hero_xl/public/images/hero/Artboard1-80.jpg?h=1771c8c6&itok=tpxriJzH)
To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Alpha-Synuclein Filament Protein
Full-Length human alpha-synuclein protein expressed in vitro and manipulated to form alpha-synuclein filaments.
Note: This filament version of alpha-synuclein was used as antigen for the MJF-14 conformation-specific rabbit monoclonal alpha-synuclein filament-specific antibody which is available at Abcam. This protein is not intended for use as a pre-formed fibril for seeding alpha-synuclein pathology in vivo or in vitro. For protein to use in an alpha-synuclein pre-formed fibril model please use the "Human alpha-synuclein monomer protein for making pre-formed fibrils" available from Proteos.
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EIF4G1 R1207H Mouse
Mice expressing the R1207H mutant form of EIF4G1. RRID:IMSR_JAX:021827
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Thy-1 Wild Type Human Alpha-Synuclein Mouse (Line 15)
Transgenic mice expressing wild type human alpha-synuclein directed by the murine Thy-1 promoter. Two separate founder lines with different expression levels are available. RRID:IMSR_JAX:017682
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Lentiviral LRRK2 (G2019S)
Lentiviral vector expressing LRRK2 mutated at residue G2019S. Lentiviral eGFP available as a control in Reporter section.
Please note: This viral vector is not intended for in vivo use.
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Alpha-Synuclein Filament-Specific Antibody*
Conformation-specific rabbit monoclonal antibody directed against the filamentous form of wild-type alpha-synuclein.
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LRRK2 Antibody (MJFF3)
Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).
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LRRK2 KO Mouse
Knockout of LRRK2 created by deletion of exons 39-40 of the LRRK2 gene in the C57BL/6N mouse strain. RRID:IMSR_JAX:016121
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Alpha-Synuclein Monomer Protein
Full-Length human alpha-synuclein monomeric protein generated in vitro.
Note: This protein was used to generate alpha-synuclein filament which was then used as antigen for the MJF-14 alpha-synuclein filament-specific antibody which is also available at Abcam.
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