To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
-
Sponsored Tools Program
Learn more about how MJFF can help share your tools.
-
Tools Consortium
MJFF is working with industry to develop priority tools.
-
Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
-
Eif4g1 KO
Mice carrying a targeted Eif4g1 mutation in which exons 24 through 28 are deleted. RRID:IMSR_JAX:024521
-
Lentiviral eGFP-LRRK2 (wild-type)
Lentiviral vector encoding wild-type LRRK2 and eGFP. Lentiviral eGFP available as a control in Reporter section.
Please note: This viral vector is not intended for in vivo use.
-
Alpha-Synuclein Antibody
Rabbit monoclonal antibody directed against wild-type human alpha-synuclein. The antibody was mapped to amino acids 118-123 (VDPDNE).
-
Wild Type Human Alpha-Synuclein Mouse
Mice express a wild-type human alpha-synuclein gene directed by its endogenous promoter/enhancer regions on the BAC transgene. RRID:IMSR_JAX:018442
-
LRRK2 Antibody (MJFF2)
Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).
-
LRRK2 Wild-type Mouse
Mice express a wild-type human LRRK2 gene directed by its endogenous promoter/enhancer regions on the BAC transgene. The human LRRK2 protein expression is approximately 5-fold over endogenous mouse LRRK2. RRID:IMSR_JAX:013725
-
Alpha Synuclein Gene Replacement E46K (SNCA-GR*E46K) Mouse*
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the E46K mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039168
-
Alpha Synuclein Gene Replacement A53T (SNCA-GR*A53T) Mouse*
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the A53T mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039167
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic