The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2014Validating BAG5 as a Therapeutic Target of Parkinson’s Disease
Objective/Rationale:
Poor handling and elimination of misfolded proteins has been identified as central in the development of Parkinson’s disease (PD). A special class of proteins within the cell... -
Rapid Response Innovation Awards, 2014Intrabodies in Pre-clinical Models of Parkinson’s Disease
Objective/Rationale:
Progressive loss of dopamine neurons and clumps of the protein alpha-synuclein are hallmarks of Parkinson’s disease (PD). Intrabodies are small antibody fragments that target... -
Rapid Response Innovation Awards, 2014Cofilin-1 as a Major Contributor to Oxidative Stress-mediated Cell Death in Parkinson’s Disease
Objective/Rationale:
Oxidative stress, a process that stops the cell producing energy efficiently, is a key cause of the death of neurons in Parkinson’s disease. We have previously shown that oxidative... -
Therapeutic Pipeline Program, 2014Characterization of a Novel Therapy To Selectively Silence Alpha-Synuclein In Monoaminergic Neurons
Objective/Rationale:
The biotech company nLife Therapeutics has designed a molecule (NLF-PD-1233) to target specific neurons in the brain to reduce expression of the protein alpha-synuclein (which... -
Rapid Response Innovation Awards, 2014Electromyography Signals as Biomarkers for Parkinson’s Disease
Objective/Rationale:
A simple, painless and reliable method to detect Parkinson’s disease at an early stage is very important to patients, doctors and researchers. Doctors want to help patients early... -
Research Grant, 2014Clinical and Neuroimaging Predictors of Cognitive Decline in Parkinson’s Disease
Objective/Rationale:
Parkinson’s disease (PD) dementia is often preceded by a phase of mild cognitive impairment (PD-MCI), for which diagnostic criteria have been recently proposed. However, there...
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Our funding programs support basic, translational and clinical research from academia and industry.