The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2021SCARB2 as a Potential Target in Parkinson’s Disease
Study Rationale:
Mutations in GBA, a gene that encodes an enzyme called glucocerebrosidase, are a common risk factor for Parkinson’s disease (PD). Inside cells, glucocerebrosidase must be escorted to... -
Target Advancement Program, 2021Targeting the Chemical Modification of DNA to Suppress Neurodegeneration in Parkinson’s Disease
Study Rationale:
Genes can be switched on or off by proteins that add and remove chemical modifications to DNA. We and others have shown that the chemical modification of genes important for... -
Target Advancement Program, 2021Modulation of Epigenetic Regulator HDAC4 as a Parkinson’s Treatment
Study Rationale:
Scientists can take skin cells from people with Parkinson’s disease (PD), turn them into stem cells, and then engineer them into dopamine neurons, the cell type lost in PD. Our... -
Therapeutic Pipeline Program, 2021Novel Inhibitors of Protein Aggregation as Potential Therapeutics for Parkinson’s Disease
Study Rationale:
The protein alpha-synuclein can aggregate in brain cells, which leads to brain cell death in Parkinson’s disease (PD). We plan to investigate a novel class of drugs — called protein... -
Environmental Risk Factors, 2021Pesticide Exposure, Systems Biology and Parkinson’s Disease
Study Rationale:
Pesticide exposure is among the most consistently and widely reported environmental risk factors for Parkinson’s disease (PD). However, research on specific pesticides in... -
Therapeutic Pipeline Program, 2021Dietary Interventions to Slow and Improve Parkinson’s Symptoms by Restructuring the Gut Microbiome and Decreasing Inflammation
Study Rationale:
There is a link between the gut and the brain in Parkinson’s disease (PD), and gut bacteria may play an important role. Gut bacteria they affect the bowel mucus barrier, produce...
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Our funding programs support basic, translational and clinical research from academia and industry.