The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2022Establishing a Parkinson’s Disease Registry in West Virginia
Study Rationale: The state of West Virginia has one of the nation’s highest rates of Parkinson’s disease (PD), a condition for which the causes are not well understood and there is no cure. In April...
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Translational Pipeline Program, 2022Development of a Nurr1 Activator as a Novel Therapeutic for Parkinson’s Disease
Study Rationale: Nurr1 is a protein that works in the nucleus of dopamine-producing nerve cells in the brain to keep these cells functioning normally. Emerging evidence suggests that impaired function...
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Research Grant, 2022Longitudinal Endpoint Optimization to Provide an Assessment of Relevant Drugs in Parkinson’s Disease (LEOPARD-PD)
Study Rationale: The Parkinson’s Disease-Health Index (PD-HI) is a novel, disease specific patient-reported outcome (PRO) measure designed for use in clinical trials to track clinically meaningful...
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Parkinson’s Pathway Molecular Data Analysis Program, 2022Assessment of Proinflammatory Cytokines as Biomarkers for Parkinson’s Disease
Study Rationale: We have generated a computer-based model that simulates alterations in molecular mechanisms associated with Parkinson’s disease (PD) genes. This model suggested that, in sporadic...
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Research Grant, 2022Examining the Role of Cannabinoid Receptor 2 in Inflammatory Responses Triggered by Alpha-synuclein
Study Rationale: There is growing interest in the anti-inflammatory properties of cannabis-related compounds as a potential therapy for Parkinson’s disease (PD). Cannabis acts on cannabinoid receptors...
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Research Grant, 2022Using Integrated Biomarkers of Prodromal Parkinson’s Disease to Assess the Efficacy of Exercise Intervention in the Earliest Phase of Disease
Study Rationale: In individuals with Parkinson’s disease (PD), the pathological processes are already advanced by the time a clinical diagnosis is made. This delay contributes to the difficulty in...
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Our funding programs support basic, translational and clinical research from academia and industry.