The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Analysis of Patient-Reported Outcomes from Fox Insight, 2021Exploring Environmental and Genetic Mediators of Progression in Parkinson’s Disease
Study Rationale:
We currently do not understand why some people with Parkinson’s disease (PD) have particularly severe symptoms, or symptoms that progress rapidly, compared to those who do not. This... -
Target Advancement Program, 2021Developing a Protein Quality Control Mechanism as a Novel Therapy for Parkinson’s Disease
Study Rationale:
Parkinson’s disease is a disorder of protein misfolding and aggregation. It is characterized by the presence of Lewy bodies and Lewy neurites: aberrant intracellular structures... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Using Risk Scores to Link Molecular Mechanisms to Clinical Outcomes in Parkinson's Disease
Study Rationale:
The symptoms and course of Parkinson’s disease (PD) show remarkable variation from one person to another, indicating differences in the underlying disease process that may also be... -
Therapeutic Pipeline Program, 2021Compounds that Enhance the Activity of GCase as a Treatment for Parkinson’s Disease
Study Rationale:
Beta-glucocerebrosidase (GCase), a protein that processes some of the key components of cell membranes, is required for normal brain function. Reduced activity of this protein... -
Therapeutic Pipeline Program, 2021Identifying Small Molecule Binders of the LRRK2 WD Domain
Study Rationale:
Individuals with genetic variations or mutations in a gene called LRRK2 are at increased risk of developing Parkinson’s disease (PD). Because these alterations enhance the activity of... -
Parkinson's Pathway Biomarkers, 2021Phospho-proteome Analysis of PBMCs in LRRK2 Mutation Carriers: Expansion & Validation of Findings of the Barcelona LRRK2 Biorepository
Study Rationale: We established a biorepository of blood cells from G2019S LRRK2-PD patients recruited at the Hospital Clínic de Barcelona (Barcelona). Using this cohort, we performed a phospho...
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